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Arch Dis Child Fetal Neonatal Ed 90:F41-F45 doi:10.1136/adc.2003.041772
  • Original article

Does smoking in pregnancy modify the impact of antenatal steroids on neonatal respiratory distress syndrome? Results of the Epipage study

Table 3

 Antenatal steroids according to risk factors of respiratory distress syndrome (RDS) among non-smokers and smokers

Non-smokers Smokers p Value*
n/N % n/N %
*Comparison of the distribution of antenatal steroids by risk factors of RDS in non-smokers and smokers.
†Intrauterine growth retardation defined as a birth weight ratio <0.74.31
‡Comparison between five exclusive groups of causes defined in the following order: hypertension, either pre-existing or due to pregnancy; maternal bleeding (abruptio placenta, placenta previa, and other uterine bleeding) without hypertension; preterm premature rupture of membranes (PPROM) without hypertension or bleeding; preterm spontaneous labour without hypertension, bleeding, or PPROM; all other causes, excluding hypertension, bleeding, PPROM of preterm spontaneous bleeding.
Antenatal steroids 384/518 221/340
Gestational age (weeks)
    27–28 62/92 67.4 46/72 63.9 0.63
    29–30 100/128 78.1 57/85 67.1
    31–32 222/298 74.5 118/183 64.5
IUGR†
    Yes 112/137 81.8 52/74 70.3 0.47
    No 271/378 71.7 169/265 63.8
Main cause of preterm birth‡
    Hypertension 157/194 80.9 29/41 70.7 0.29
    Bleeding 81/117 69.2 72/113 63.7
    PPROM 74/91 81.3 53/81 65.4
    Spontaneous prelabour 43/81 53.1 41/71 57.7
    Other 29/35 82.9 26/34 76.5
Caesarean section
    Yes 271/352 77.0 132/196 67.3 0.8
    No 112/165 67.9 89/144 61.8
Sex
    Boys 210/281 74.7 116/177 65.5 0.93
    Girls 173/236 73.3 105/163 64.4

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