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Arch Dis Child Fetal Neonatal Ed 90:F49-F52 doi:10.1136/adc.2003.048785
  • Original article

Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?

Table 2

 Multivariate analysis of association of severe hyperoxaemia and/or severe hypocapnia with adverse outcome during the first 20–120 minutes of life in infants with birth asphyxia (n  =  139), controlling for disease severity

Variable OR 95% CI p Value
Severe hyperoxaemia and severe hypocapnia were defined as Pao2 >26.6 kPa (200 mm Hg) and Paco2 <2.6 kPa (20 mm Hg) respectively.
*Time from birth in minutes to establishment of a regular breathing pattern.
†First available base deficit, measured in SDs from mean normal values.
Severe hyperoxaemia or severe hypocapnia 3.07 1.31 to 7.18 0.001
Severe hyperoxaemia and severe hypocapnia 4.56 1.4 to 14.9 0.012
Time to regular breathing* 2.29 1.00 to 5.22 0.049
Number of blood gases NS
Base deficit† NS
5 min Apgar score NS

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