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Arch Dis Child Fetal Neonatal Ed 90:F235-FF239 doi:10.1136/adc.2004.057638
  • Original article

Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management

Table 5

 Continuous clinical variables adjusted for gestational age and clinical risk index for babies (CRIB) score

Outcome Median (Q1–Q3)* Adjusted HR p Value
HR 95% CI
Analysis was performed using Cox proportional hazards regression. Adjusted HRs were obtained in a multivariate regression model. In all regression models, data for infants who died (n  =  24, table 3) or were transferred (group 1, 2, 3: n  =  3, 1, 3 respectively) were censored. No significant effects of sex and intrauterine were found in addition to gestational age at delivery and CRIB score.
*Q1 and Q3 list the number of days that 25th and 75th centiles of infants remained on ventilation, oxygen, or stayed in the hospital.
PDA, Patent ductus arteriosus; HR, hazard ratio.
Duration of ventilation 25 (7–53)
    PDA insignificant 14 (4–31) 1.00
    PDA closed 37 (20–62) 0.86 0.63 to 1.19 0.336
    PDA open 60 (41–75) 0.70 0.44 to 1.11 0.130
Duration of oxygen 62 (20–103)
    PDA insignificant 48 (20–103) 1.00
    PDA closed 90 (76–103) 0.89 0.63 to 1.27 0.526
    PDA open 85 (44–120) 1.20 0.73 to 1.98 0.476
Hospital stay 91 (71–119)
    PDA insignificant 80 (65–100) 1.00
    PDA closed 111 (8–127) 0.75 0.53 to 1.07 0.177
    PDA open 111 (94–159) 0.85 0.48 to 1.50 0.579

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