Neonatal pure red cell aplasia due to anti-M
- R F Hinchliffe1,
- B Nolan1,
- A J Vora1,
- R Stamps2
- 1Department of Paediatric Haematology, Sheffield Children’s NHS Trust, Sheffield, UK
- 2National Blood Service, Sheffield
- Correspondence to:
A J Vora
Department of Paediatric Haematology, Sheffield Children’s NHS Trust, Western Bank, Sheffield S10 2TH, UK;Ajay.Vora{at}sch.nhs.uk
Haemolytic disease of the newborn (HDN) is caused by maternal immunoglobulin (Ig) G acting against antigens expressed on mature fetal red cells. Anti-M antibodies active at 37°C are a rare cause of HDN.1 We report data, arising from the investigation of a neonate with severe transient pure red-cell aplasia, indicating that anti-M can cause hypoplastic HDN by inhibition of erythroid precursor growth, as frequently occurs with anti-Kell antibodies.2
A female neonate presented at 4 weeks of age with severe hypoplastic anaemia (haemoglobin 3.7 g/dl, reticulocytes …
