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Arch Dis Child Fetal Neonatal Ed 2007;92:F402-F403 doi:10.1136/adc.2006.101717
  • Short report
    • Short report

Angiotensin-converting enzyme inhibitor fetopathy: long-term outcome

  1. Guido F Laube1,
  2. Markus J Kemper1,
  3. Gregor Schubiger2,
  4. Thomas J Neuhaus1
  1. 1Nephrology Unit, University Children’s Hospital
    Zurich, Switzerland
  2. 2Children’s Hospital
    Lucerne, Switzerland
  1. Dr Guido F Laube, University Children’s Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland; guido.laube{at}kispi.unizh.ch
  • Accepted 31 December 2006
  • Published Online First 6 February 2007

Abstract

Fetal exposure to angiotensin-converting enzyme inhibitors (ACEIs) is associated with increased neonatal morbidity and mortality. Long-term follow-up of three patients with fetal ACEI exposure revealed impaired renal function in two, severe hypertension and proteinuria in one and isolated polycythaemia in all three. Careful long-term follow-up of children with ACEI fetopathy is recommended.

Footnotes

  • Competing interests: None.

  • Abbreviations:
    ACEI
    angiotensin-converting enzyme inhibitor
    GFR
    glomerular filtration rate

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