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Arch Dis Child Fetal Neonatal Ed 2009;94:F236-F240 doi:10.1136/adc.2008.146035
  • Original article

Toxic additives in medication for preterm infants

  1. A Whittaker1,
  2. A E Currie1,
  3. M A Turner2,
  4. D J Field3,
  5. H Mulla4,
  6. H C Pandya5
  1. 1
    Neonatal Unit, Leicester Royal Infirmary, University Hospitals Leicester NHS Trust, Leicester, UK
  2. 2
    Division of Perinatal and Developmental Medicine, University of Liverpool, Liverpool, UK
  3. 3
    Department of Health Sciences, University of Leicester, Leicester, UK
  4. 4
    Centre for Therapeutic Evaluation of Drugs in Children, University Hospitals Leicester NHS
  5. 5
    Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK
  1. Dr H C Pandya, Department of Infection, Immunity & Inflammation, University of Leicester Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK; hp28{at}le.ac.uk
  • Accepted 21 October 2008
  • Published Online First 21 January 2009

Abstract

Background: Little is known about exposure of preterm infants to excipients during routine clinical care.

Objective: To document excipient exposure in vulnerable preterm babies in a single centre, taking into account chronic lung disease (CLD) as a marker of illness severity.

Design: Excipient exposure after treatment with eight oral liquid medications was determined by retrospectively analysing the drug charts of infants admitted to a neonatal unit.

Setting: The Leicester Neonatal Service.

Participants: 38 infants born between June 2005 and July 2006 who were less than 30 weeks’ gestation and 1500 g in weight at birth and managed in Leicester to discharge.

Results: The 38 infants represented 53% of the eligible target group; 7/38 infants had CLD. During their in-patient stay, infants were exposed to over 20 excipients including ethanol and propylene glycol, chemicals associated with neurotoxicity. Infants with CLD were exposed to higher concentrations of these toxins. Infants were also exposed to high concentrations of sorbitol, with some infants being exposed to concentrations in excess of recommended guidelines for maximum exposure in adults.

Conclusions: Preterm infants are commonly exposed to excipients, some of which are potentially toxic. Strategies aimed at reducing excipient load in preterm infants are urgently required

Footnotes

  • Competing interests: None.

Responses to this article

  • Alcohol Intake in Infants Treated with Oral Furosemide Solution
    • Dolores C. Iaboni
    Arch Dis Child - Fetal Neonatal Ed published online July 22, 2009
  • Additives in medication for preterm infants: documentation of exposure is only the first step…
    • karel allegaert
    Arch Dis Child - Fetal Neonatal Ed published online June 29, 2009

This Article

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  4. All versions of this article:
    1. adc.2008.146035v1
    2. 94/4/F236 most recent

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