Sildenafil use in congenital diaphragmatic hernia
- L Hunter1,
- T Richens2,
- C Davis1,
- G Walker1,
- J H Simpson1
- 1Neonatal Intensive Care Unit, Royal Hospital for Sick Children, Glasgow, UK
- 2Department of Cardiology, Royal Hospital for Sick Children, Glasgow, UK
- Correspondence to Lindsey Hunter, Flat 3/2, 15 Malta Terrace, Glasgow G5 OTN, UK; lhunter{at}doctors.org.uk
- Accepted 6 December 2008
The postnatal management of severe congenital diaphragmatic hernia (CDH) remains challenging with few robust evidence-based interventions but many therapies based on case reports or small case series. A good example of this is sildenafil, a phosphodiesterase inhibitor, which is increasingly used in the management of pulmonary hypertension associated with CDH.1 2
We retrospectively audited sildenafil use in all infants with CDH managed in the co-located Queen Mother’s Hospital and the Royal Hospital for Sick Children, …
