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Arch Dis Child Fetal Neonatal Ed doi:10.1136/adc.2007.121962

Systemic antifungal prophylaxis for very-low-birth-weight infants: systematic review

  1. Linda Clerihew
  1. Wishaw Hospital, United Kingdom
    1. Nicola Austin
    1. Christchurch Women's Hospital, New Zealand
      1. William McGuire (william.mcguire{at}act.gov.au)
      1. Australian National University, Australia
        • Published Online First 3 September 2007

        Abstract

        Systematic review and meta-analysis of four randomised controlled trials suggests that prophylactic fluconazole reduces the incidence of invasive fungal infection in very-low-birth-weight infants. Further trials are needed to provide more precise estimates of effect size, and to assess the effect on mortality, neurodevelopment, and the emergence of antifungal resistance.

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