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Arch Dis Child Fetal Neonatal Ed doi:10.1136/adc.2007.125377

Transient neonatal diabetes mellitus in extremely preterm infant

  1. Shigeru Nishimaki (nishimakishigeru{at}yahoo.co.jp)
  1. Department of Pediatrics & Neonatology, Yokohama City University, Japan
    1. Tomohide Yukawa
    1. Department of Pediatrics & Neonatology, Yokohama City University, Japan
      1. Yoshio Makita
      1. Department of Pediatrics, Asahikawa Medical College, Japan
        1. Hidekazu Honda
        1. Department of Pediatrics, Yokosuka Kyosai Hospital, Japan
          1. Nobuyuki Kikuchi
          1. Department of Pediatrics, Yokohama City University, Japan
            1. Susumu Minamisawa
            1. Cardiovascular Reseach Institute, Yokohama City University, Japan
              1. Shumpei Yokota
              1. Department of Pediatrics, Yokohama City University, Japan
                • Published Online First 11 January 2008

                Abstract

                This is the first report of transient neonatal diabetes mellitus (TNDM) in an extremely preterm infant (gestational age: 27 weeks, birth weight: 718 grams). The patient had

                IUGR and developed hyperglycemia on the first day of life. Insulin administration was discontinued on the 89th day of life, which was one day before the original due date.

                This case suggests that (1) insufficient insulin secretion started at least from the second trimester of the pregnancy; (2) the duration needed for recovery of insulin secretion was not dependent on the maturity.

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